Penelope is a Research Training Network (RTN) which is funded by the European Commission within the 6th Framework Programme. Penelope was kicked off in April 2007 and will run for 4 years.
The overall goal of Penelope is to gain quantitative understanding of the nature and evolution of protein interaction networks in eukaryotes. This challenging aim will require the application of a broad range of methods and technologies, ranging from structural biology, biochemistry, genetics and genomics to advanced light microscopy and simulation tools for cell networks. Penelope will provide a unique opportunity for interdisciplinary training of early-stage and experienced researchers.
focuses on the study of the interplay between Src Homology 3 (SH3) domains, their host proteins and their binding partners (or target ligands) in four different yeasts, i.e. Saccharomyces cerevisiae
, Candida albicans
, Ashbya gossypii
and Schizosaccharomyces pombe
. The four yeast species encompass roughly a thousand million years of evolution. The RTN intends to characterize the presently known interactions and to identify hitherto undetected interactions. Comparative analysis across the four genomes will allow us to investigate how new interactions were added to a network as well as how they were lost.